The faculty in MBM are united by a common interest in the biology of microbes (bacteria, fungi, viruses, and parasites) and the effects of microbes on human and animal hosts. The microbial pathogens program studies microorganisms that cause infectious diseases, with emphasis on rigorous analysis of these pathogens and the immune responses that restrict them. Program investigators direct detailed studies of pathogenic bacteria, viruses, fungi and eukaryotic parasites. Research topics include structural analysis of virus entry, viral evolution, viral oncogenes, intracellular bacterial pathogens, microorganisms that cause diarrhea and pneumonia, intracellular signaling, pathogen adhesion, genetic determinants involved in susceptibility to infection, vaccine development, and identification of novel antimicrobial agents.Work in collaboration with the senior investigator in the host laboratory. S/he works independently to participate in or lead a portion of a research project or projects. The research associate contributes ideas and suggestions to the research effort, operates independently and publishes papers in collaboration with the senior investigator. This individual may have other responsibilities in the laboratory such as supervision of staff, training of graduate students or postdoctoral fellows, grant proposal writing, writing papers, etc. Research in the host lab is focused on quantitative biology, bacterial cell physiology, drug persistence and resistance, drug regimen design, imaging, mathematical modeling, signal transduction, and methods development. The focus area is tuberculosis.